Postmenopausal Vitamin D Requirement

Postmenopausal Vitamin D Requirement

April 02, 2012

2 min read

Vitamin D dose response in postmenopausal women can be used as recommended daily allowance guide

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Data from a dose-response study confirm the Institute of Medicine's current recommendation for the dietary allowance and estimated average requirement for vitamin D in postmenopausal women.

Currently, the Institute of Medicine states that vitamin D levels should be 600 IU/day in women aged younger than 70 years and 800 IU/day in women aged older than 70 years.

"Our overall goal was to determine the [recommended daily allowance] and [estimated average requirement] of vitamin D3 based on the response of serum [25-hydroxyvitamin D] to various doses of vitamin D3. Our results can be used to guide future trials of clinical outcomes, such as fractures, cancer and heart disease," the researchers wrote.

J. Christopher Gallagher, MD, professor of medicine and director of the bone metabolism unit at Creighton University School of Medicine, and other researchers designed a 1-year, multiple dose response, randomized, placebo-controlled trial for 163 healthy postmenopausal white women aged 57 to 90 years and at least 7 years postmenopausal with insufficient vitamin D levels.

The participants' serum 25-(OH)D levels were screened before random assignment. Based on 25-(OH)D levels of less than 37.5 nmol/L vs. levels of at least 37.5 nmol/L, participants were randomly assigned to one of seven vitamin D3 doses: 400 IU/day, 800 IU/day, 1,600 IU/day, 2,400 IU/day, 3,200 IU/day, 4,000 IU/day and 4,800 IU/day, or placebo for 1 year.

Each participant was administered one vitamin D3 capsule in the morning, besides a calcium supplement (Citracal, Bayer HealthCare), twice daily to establish a calcium intake of 1,200 mg/day to 1,400 mg/day, based on a 7-day food diary.

BMI had a significant effect on 25-(OH)D levels and vitamin D3 dosage. Overweight participants had levels 12.5 nmol/L lower and obese participants had levels 17.5 nmol/L lower than participants with normal BMI.

The researchers concluded that 25-(OH)D levels increased with higher doses of vitamin D3 and flattened at 112 nmol/L with vitamin D3 doses of 3,200 IU/day to 4,800 IU/day. At vitamin D3 800 IU/day, 25-(OH)D levels increased more than 50 nmol/L in 97.5% of participants.

For additional clinical outcomes, the researchers said recommended daily allowance and estimated average requirement must be determined in future trials.

Disclosure: Dr. Gallagher reports the organization has received a grant from the National Institutes of Aging and funding to support travel to meetings for the study or other purposes. Additionally, Dr. Gallagher reports Mission Pharmaceutical, which initially supplied the calcium citrate (Citracal) at no cost for the study, was bought by Bayer HealthCare in the middle of the study. Bayer HealthCare did not provide additional financial support. No other relevant financial disclosures were reported.

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Postmenopausal Vitamin D Requirement

Source: https://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/%7B77e1d001-47e7-478c-aa07-cf8a897e9aa4%7D/vitamin-d-dose-response-in-postmenopausal-women-can-be-used-as-recommended-daily-allowance-guide

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